2nd EADGENE Workshop on Mastitis 1-2 March 2007, Roslin Institute, UK

At this meeting EADGENE Mastitis Working Group presented their latest data and there was discussion of how other EADGENE work packages might contribute to the further exploration of the original transcriptome profiling data generated by the mastitis experiments.

 Programme

Please click on highlighted titles to download a editted pdf of the presentation.  More detailed versions of these presentations are available for Mastitis Working Group members in the Intranet.

Thursday 1st March 2007: Mastitis in cattle (16:00 -18:30)

Welcome and Introduction - Hans-Martin Seyfert (RIBFA, Germany), Liz Glass (Roslin Institute, UK)
EADGENE Technology Transfer: opportunities to link the mastitis working group with industry - Nigel Otter (Merial, UK), Angela van der Sanden (EFFAB, NL)
Regulated Genes in the Bovine Mammary Gland During E. coli and S. aureus Infection - Kirsty Jensen, Liz Glass, (Roslin Institute, UK) & the RIBFA group(Germany)
Overview of the Microarray Data Analysis Workshop using the EADGENE Mastitis data - Dirk-Jan de Koning (Roslin Institute, UK)
Comparative cytokine profiles of cows following udder infections with E. coli or S. aureus.
Primary bovine MEC: immune competence and analytical tools to dissect pathogen-specific signal transduction - Juliane Günther, Wei Yang & Hans-Martin Seyfert (RIBFA, Germany)
Update on host responses to S. uberis infection by microarray analysis and real time PCR - Astrid de Greeff et. al. (Animal Sciences Group Lelystad, NL)
S. Uberis infections, New Zealand experiences - Hans-Martin Seyfert (RIBFA, Germany)

Friday 2nd March 2007: Mastitis in cattle, sheep and goats 

Interaction of bovine macrophages and Staph. aureus strain from clinical mastitis - Ingrid Olsaker, Guro Boman (NSVS, Norway)
Early Host-Pathogen Interactions during Mastitis in Experimentally-infected Sheep - Gilles Foucras, Dominique Bergonier, and Rachel Rupp (INRA, France)
Mastitis in goats: Update on the Italian program - Paolo Moroni, Alessandra Stella (PTP, Italy)
Discussion:  Summarizing discussion on data currently available from the EADGENE mastitis group: Differences between E. coli vs. S. aureus / S. uberis elicited immune responses in the udder.
SABRE WP5:  Mammary function. Exploiting the breeding population to resolve genetics of mastitis susceptibility - Mogens Sandø Lund (University of Aarhus, Denmark)
Development of the EADGENE Mastitis concept: from the pathogen-regulated host genes towards relevance. WP08: Operational Genomics. Sem Genini, Elisabetta Giuffra (PTP)

Forward Planning Discussion:
• Work plan for the Mastitis Working group
• How to incorporate and exploit data bases concerning (i) DNA-sequences, (ii) transcription factors
• Quantitative genetics: (i) resources available for SCS genotyped breeding population(s)/ bulls? (ii) availability of genotype-selected bulls for comparative sequence analyses of selected genes; (iii) which genetic design is feasible and available
(iv) potential overlap (negative) or team-up (positive) with SABRE?
(v) The next steps!